Talk at 2025 ISPE, San Francisco

Together with experts from CSL Behring and ZETA, INOSIM’s Dominik Aubel will present a talk about the role of process simulation in Digital Transformation and Pharma 4.0 with the title:

Creating Value with Digital Twins for Batch Plants

Tuesday, 28th January 2025, 11:15 – 11:45.

Abstract:

In the face of energy shortages, rising prices, shorter time-to-market, and increasing competitive pressure, speed, flexibility, and maximum efficiency are more important than ever in the process industry. These goals can only be achieved through fully digital data management and seamless integration of digital tools over the complete lifecycle of a production plant. This presentation provides insights into how CSL Behring’s new €400 million plasma fractionation plant in Marburg, Germany, was engineered and is operated using an integrated digital approach that employs highly accurate Digital Twins at each stage. The benefits are manifold: In the early phases, process alternatives were quantitatively compared, capacities estimated, or equipment sizes determined; in later phases, detailed workflows were developed, subsystems for cleaning, utilities, buffers, or resources were designed, process robustness under uncertainties ensured, optimal operating modes identified, automation and production planning developed, and commissioning supported. After commissioning, the Digital Twin was re-used in the new solution INOSIM Foresight for operations support. With accurate dynamic predictions, the solution supports the operating staff in all aspects of operation – whether through real-time planning of production, personnel, and resources, predicting and “combating” disruptions, optimal maintenance planning, efficient onboarding of new employees, and many other use cases.

Please find more information in the event’s program.